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gene correlations in between two groups

Hi all,

I have a simple question. I have a dataset containing 14 normal tissues and 6 cancerous tissues. I want to perform correlation analysis between two groups for each gene in this data set. But I couldn't figure out how to do it and couldn't find it.

Thanks

gene-expression correlation
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written by biology_inform • biology_inform

What is "correlation analysis", like WGCNA?

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written by ATpoint ATpoint

To be more clear, I have RNAi data from depmap with different cell lines and I separated them into two groups according to their EGFR mutation status (WT vs mutant). I want to find the genes that are essential for only WT group. If is there any other way to find it, I would be appreciated. Thanks

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written by biology_inform • biology_inform

Use specialized software to analyse CRISPR/RNAi data, such as MAGeCK.

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written by ATpoint ATpoint

Thanks. But they are already analyzed. Afaik it analyzes raw data. In my dataset for each gene there is score. I want to interpret the data to find the genes that essential only for the WT cell lines

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written by biology_inform • biology_inform

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