Association Study

I have completed an Alzheimer's disease association study in PLINK, but no significant SNPs were found.I checked my raw data VCF file and the risk factor SNP and rsid present, but it is not present in the GWAS results.

My sample size is 102: 35 cases and 67 controls.

Can anyone please explain?

gwas plink

• 986 views • link

updated 2.9 years ago by Ram

• written 2.9 years ago by karthick •

any one explain

This is not good etiquette. See how I've changed it. Please try to be polite and professional.

• 0 views • link

written 2.9 years ago by Ram

1 answer

You just lack power I guess. 35 cases vs 67 controls is a very small sample size for an association study...

• 0 views • link

written 2.9 years ago by raphael.B •

More posts like this

GWASQC
written 1.9 years ago by karthick •

I am performing GWAS analysis on the ADNI dataset (WGS CASAVA Illumina dataset) using the PLINK tool for quality control (QC). However, Alzheimer's disease risk …
ADNI DATASET
written 2.9 years ago by karthick •

I have GWAS analysis in the ADNI dataset (WGS CASAVA Illumina software dataset). I have GWAS analysis using the plink tool in QC, but alzheimer …
plink QC
written 3.0 years ago by karthick •

we perpose in identify rick factor snp in my alzhimer's disease dataset in GWAS analysis case and control study. i don't understand plink gwas, any …
Significant SNPs related to a specific trait selection by Baysian (BayesR) GWAS
written 7.4 years ago by Chapa •

Can anyone explain how to select significant SNPs associated with one trait by BayesR derived manhatton plot (Bayesian Genome Wide Association Study)(x axis=chromosome, Y axis …
Estimate signifiant loci in GWAS
written 9.5 years ago by alessandrotestori7

Hi! Assume that a Genome Wide Association Study (GWAS) yields three significant SNPs related to a disease; another GWAS yields two more SNPs (different from …
SNP genotyping and analysis of association with phenotype
written 10.0 years ago by orzech_mag

Dear colleges, I would like to analyse the association of few SNPs with phenotypes and summarize if those SNPs may cause increased risk or normal …
How can overdominant genotype model contribute to disease risk?
written 10.4 years ago by akira •

We have performed an association study between SNPs and a disease. We found a significant association between one SNP (C/T) and the disease in overdominant …
Genome-wide cox regression in R
written 11.8 years ago by Caragh •

I am working on a genome-wide association study. I wish to examine the time to onset of a disease in relation to the alleles present …
Logistic regression with Plink - conditioning to SNPs
written 12.0 years ago by Kasiopea •

Hi all, I'm seeking to interpret the results of a logistic regression analysis with Plink. I'm analyzing data from a genetic case-control association study (of …
small case-control exome sequencing study
written 12.1 years ago by User6891

Hi everyone, I have exome data of 25 unrelated patients and 40 unrelated control samples. I'm looking for rare variants associated with the disease. I've …