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PRSice-2 using SNPs with extremely low P-value

I would like to construct a Polygenic risk score using PRSice-2. However, our summary statistics contains a very small P-value, such as P-value=5.0x10^-1200. Perhaps that is why we cannot use this summary statistics to construct the PRS. How can I solve this problem? I would be grateful if you could enlighten me.

prsice-2 snp
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written by Apprentice Apprentice

1 answer

I had asked the same question on PRSice's git hub. I got an answer from the developer and will share it here as well. https://github.com/choishingwan/PRSice/issues/320

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written by Apprentice Apprentice

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