RSEM expression values
In RSEM.isoform.TMM.EXPR.matrix, some values for a set of 3 samples are like this:
0.596 0.782 0
2.173 0 0
4465.372 3953.622 5033.097
Why there is so much difference between samples and among different transcripts?
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Biological heterogeneity or technical artifacts sich as batch effects. This really cannot be answered meaningfully without context.