What are the differences between GSVA and ssGSEA (in layman's term)?
I know the Bioconductor vignettes for GSVA has a decent description of the methodological differences between the algorithms. However, I am still confused with the technical terms. May I know if there are any further references that explain these algorithms in layman's terms?
- I am interested to know if there are certain scenarios in that either algorithm has been proven (or suggested) to perform better.
- Whether the "scores" derived from these algorithms can be interpreted in a similar way? I found that GSVA scores tend to center around 0. May I know if this is an "artifact" (or intended output) due to its algorithm?
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