Dear all,

I have encountered a weird issue when running the Signac function seqlevelsStyle() from GenomeInfoDb package.

This function is supposed to allow users to "translate" some genomic annotations to different formats. These formats are NCBI, dbSNP and UCSC. It's done by running for example:

seqlevelsStyle(annotations) <- 'NCBI'

This works for me for all formats except for UCSC, which gives me the following error:

Error in function (type, msg, asError = TRUE) : Failed to connect to ftp.ncbi.nlm.nih.gov port 21: Connection refused

I am running this from a cluster, so I thought it might be something to do with proxys, but as the other formats (again, dbSNP and NCBI) seem to work I wonder if there is an issue with their servers that hasn't been notified? or am I doing something wrong?

For extra clarification I am using the Mouse genome, this is the full code that gives the error:

annotations <- GetGRangesFromEnsDb(ensdb = EnsDb.Mmusculus.v79)
seqlevelsStyle(annotations) <- 'UCSC'

I am using GenomeInfoDB version 1.34.4

Thank you!