Dear all,

I am applying a rare variant burden test on cases and controls. I would like to apply dominant, recessive, and double-heterozygous models, as mentioned in Chen et. al., 2022. As mentioned in their study, I would like to select the samples belonging to one or more of these models if they satisfy the following conditions:

ACi is the alternate allele count for each variant i in a gene for a sample.

I was wondering if there is any software that I can use for this purpose. Thank you very much in advance.

All the best,