SceToSingleCellAssay convert large matrix "Problem too large error"
I am trying to use MAST to identify DEGs from my single-cell RNA-seq experiment. I have a matrix (30,000 x 50,000) ready in Scanpy, and I input the matrix to MAST. The first step is to use the SceToSingleCellAssay() function. However, I always get this "Problem too large error". I was wondering if there is a way to bypass this. Using an interactive interface with 96 CPUs and 600 GB RAM. I know this may be overkill, but it still through me the error. Anything would help!
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