Hey All!

Does anybody please know why there are associations in the GWAS Catalog, that are associated with the same reported trait and SNP ID but a different effect size? I'm looking into PRS calculation and I don't know how to handle such situations. Could somebody please explain the calculation process in this scenario or provide a link to some study or literature with explanation?

For example in rs704 from study by Emilsson V from the link below:

https://www.ebi.ac.uk/gwas/variants/rs704

The only difference I can see between the reported associations is in the column P-value annotation.

Any help would be much appreciated, Thanks!