Hi there,

I wanna to compare two sets of samples in order to see how similar they are. The classical approach, for example, is a correlation or distance analysis: dendrograms, correlation heatmaps, etc.

But I was wondering if it exists some approach which does something contrary to classical differential analysis... I mean, instead of looking for statistically "divergent" genes between two conditions, search for genes that are very similar (but with a statistical background). Just for curiosity.

For example, what if we take those genes not differentially expressed according DESeq2? They mean that are similar between both conditions??

Thanks.