The number of controls in RNA-seq
Hello
I have RNAseq of miRNAs so the number of tested miRNAs are 1640
I have 2 healthy samples versus 12 cancer samples
Does it Statistically make sense to compare two controls with 12 cancers?
Can I trust the p-value in differential expression?
Thank you
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Cross-posted and answered by both the DESeq2 and edgeR developers: https://support.bioconductor.org/p/9142746/