This is a test version of Biostars. For the public version, visit https://www.biostars.org.
how to get gene start position (from annovar?) for regenie step 2 burden test

Hi,

I was using annovar to do annotation and was preparing files for rare variant tests using regenie. I have 2 questions wan to ask.

  1. regenie step2 for burden test requires a set list which needs gene (start) position. How do I get this gene position? Can I get it from annovar? I did not see this information from my annovar output and am really confused. Or can I use the position from a variant which belongs to this gene for this set list file?
  2. In annovar annotation output, I noticed 'None' in Gene.refGene (e.g., "NONE;DDX11L1") column for intergenic. How to understand/deal with that "NONE"? Can I treat this "NONE;DDX11L1" as "DDX11L1"?

Thanks very much!

position regenie variant gene rare annotation annovar

0 answers

No answers yet.

Log in to answer this question.