Hello!

I am analyzing datasets with some having UMI-counts matrices, but some being read-counts matrices (they were sequenced with technologies that do not incorporate UMIs). According to this paper (UMI-count modeling and differential expression analysis for single-cell RNA sequencing (2018)), the two types of counts have different distributions, which (if I am correct in my understanding), may make comparing them not as statistically valid. Are there any software or packages (preferably in R) that can analyze both while still being statistically sound?

Thank you for reading!