Please, can someone suggest to me a bioinformatics tool for de-novo clustering in virome? I would like to use DADA2 (as AVS clustering tool) plugin of QIIME2, but it looks specific for 16S rRNA gene amplicon sequencing and I am not sure it will work well in our case. So I am considering using UCLUST/CD-HIT/ESPRIT or Mothur (for the OTU clustering), UNOISE2/DEBLUR2 (for the ASV), but all of them are specific for 16S/18S rRNA sequences. Thank you for your help.