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DeSEQ2: Setting independentFiltering and CooksCutoff F

Hi,

I want to kindly ask what would be the effect of setting both IndependentFiltering and CooksCutoff FALSE?

I have already pre-filtered the data through the following

     keep <- rowSums(counts(ddsTxi))>=10
     ddsTxi<-ddsTxi[keep,]
deseq2 deseq2 deseq2

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