Is it advised to use quantile normalization for scRNA-seq data?

I am currently developing an analytical tool for scRNA-seq data, and I am trying club couple of normalization techniques in that tool. Is it good to keep quantile normalization as an option for the user too?

scrna-seq quantile normalization single-cell

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updated 5.0 years ago by Kevin Blighe 9.0K • | written 5.0 years ago by saqlain 9

Sure, why not? You would need to control for dispersion, though. Take a look at limma-voom

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written 5.0 years ago by Kevin Blighe 9.0K

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