Hi there, I am working with protein data. I have a bunch of samples for different experimental conditions. My collaborator ran the whole matrix through a log transformation and then ran LOESS normalization in InfernoRDN. I was wondering if someone could point me to a resource for understanding what the LOESS normalization is doing. I found the source code for performing the normalization here and I know the collaborator used all the default parameters. I would like to understand how the code actually works and what the resulting values represent. Any help appreciated. Thanks!