the fixed-effects model matrix is column rank deficient when adding a variable
I'm computing LIMMA on a RNAseq Data. When I use this formula:
~feature + age + (1 | sex) + (1 | group) + (1 | id)
inside voomWithDreamWeights() I have no problems. When I add a variable to this formula I have the following error:
Error in .fitVarPartModel(exprObj, formula, data, REML = REML, useWeights = useWeights, :
the fixed-effects model matrix is column rank deficient (rank(X) = 339 < 340 = p);
the fixed effects will be jointly unidentifiable
Suggestion: rescale fixed effect variables.
This will not change the variance fractions or p-values
age and the variable that gives me this problem are continuous variable.
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