Power analysis to determine sample size for a single-cell sequencing study
I am looking into designing a study where the interest is to capture the effect of a drug on gene expression profiles (specific to cellular clusters) in patient's samples before and after the drug administration. Is there a power analysis equivalent for single-cell sequencing to determine the minimum number of patient samples required to see any effect?
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What do you mean by cellular heterogeneity exactly?
I have updated the question. I meant to capture gene expression changes.