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The effect of metabolomics on other omics

Dears,

I am studying the relation between metabolomics and other omics, while I am reading this paper:

https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-016-0143-y

I couldn't understand the transcriptional regulation and epigenomic interactions in figure 2 Could anyone help me, please?

relation between multi omics beyond central dogma

metabolomics multiomics

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