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Sequence Depth Genome

how is average sequence depth calculated from number of reads and read length

sequence depth-of-coverage homework
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updated by Boboppie • Boboppie • written by Oduro • Oduro

2 answers

I understand this concept as equivalent to coverage.

On a genome it means that each base has been sequenced a number of time.

Coverage = (Nb of Reads)*(Read Length) / (Genome Size)

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written by Pasta • Pasta

I think the second line should read:

On a genome it means that each base has on average been sequenced a number of time.

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written by Chris Evelo Chris Evelo

Relevant questions are:

@Istvan Albert pointed to the "Coverage" section of "Shotgun sequencing" on Wiki, same as @pasta.

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updated by Ram Ram • written by Boboppie • Boboppie

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