Do you have some methods in mind on how to infer gene/gene interactions from gene expression profiling? I have a co-culture system and expression profiling had been done. Now I want to do similar work, thanks!
Predicting Host-Pathogen Gene Interaction Networks
Background
What we have are:
- ~20 genome sequences for a host species that come with gene annotations
- Several sequenced genomes for parasite/pathogens of these hosts
Question
What are the possible ways of predicting gene-to-gene interactions or gene regulatory networks between hosts and parasites?
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Gene/gene interactions and gene regulatory networks are largely inferred from gene expression profiling; I do not know of a way to do that from DNA. You may be able to infer some functionality based on DNA sequence and perhaps even about gene-gene interactions based on interactions in other species, but I don't think that is what you are asking.
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Are your "genomes" actually transcriptomes, or are they truly DNA?
They are fully assembled genomes, coding and non coding dna