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Predicting Host-Pathogen Gene Interaction Networks

Background

What we have are:

  • ~20 genome sequences for a host species that come with gene annotations
  • Several sequenced genomes for parasite/pathogens of these hosts

Question

What are the possible ways of predicting gene-to-gene interactions or gene regulatory networks between hosts and parasites?

genomics interaction network

Are your "genomes" actually transcriptomes, or are they truly DNA?

They are fully assembled genomes, coding and non coding dna

1 answer

Gene/gene interactions and gene regulatory networks are largely inferred from gene expression profiling; I do not know of a way to do that from DNA. You may be able to infer some functionality based on DNA sequence and perhaps even about gene-gene interactions based on interactions in other species, but I don't think that is what you are asking.

Do you have some methods in mind on how to infer gene/gene interactions from gene expression profiling? I have a co-culture system and expression profiling had been done. Now I want to do similar work, thanks!

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