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Predicting Snps Or Ptms After Taking A Drug

Is there a way to find where a drug (targeting a biomarker) will have its impact on a protein or a gene (seq-wise). And eventually would impact their activity and doing some PTMs or SNPs. Can anyone please provide any DB links or something?

protein gene drug
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updated by Ram Ram • written by Nims • Nims

Please have another go at phrasing the question, its unclear

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written by cdsouthan cdsouthan

2 answers

If I understand the question http://www.pharmgkb.org/ has what you are after for the SNPs at any rate. There are few if any data sets on PTM direct affects on drug binding exept for inhibition of phosphorylated kinases

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written by cdsouthan cdsouthan

I do know about PharmGKB that is has this type of data. But this set of data is not included in download files. So is there any alternative. And also is there any database that says this drug may bind to this domain of protein?

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written by Nims • Nims

ChEMBL x-refs the InterPro and Pfam domains for dug binding

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written by cdsouthan cdsouthan

Can you please specify from where I could get the X-refs. I could not find any IPR link on portal. Is it in download files. If yes, can you little elaborate.

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written by Nims • Nims

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