What'S The Biological Meaning Between Two Group (They All Same Family) When Dn/Ds Less Than 1 But One Is 0.5 And The Other Is 0.01

Question

[harrymao20]

for detail one protein X by dNdS calculation

fish urchin dN/dS =0.5

human mus dN/dS = 0.01

what’s the biological meaning between two group

how to explain their difference with this protein X

and please recommend some paper about this

[Neilfws]

Please improve this question or it will be closed. What problem are you trying to address? What have you tried so far? Provide more detail; the question is currently too terse and brief to be understood.

Answer 1

[Charles Warden]

You will need to calculate the confidence interval for each ratio. If human/mus is significantly smaller than fish/urchin, then you could argue that the gene divergence is smaller for human/mouse. However, you will need to be careful to take overall divergence into consideration as well.

For example, this paper mentions comparsions of divergence rates at different locations in the same species (where bootstrapping was used to define the confidence interval):

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.0020163

However, your comparison is tricker because your simulation will have to take the background subsitution rates into consideration