for detail one protein X by dNdS calculation
fish urchin dN/dS =0.5
human mus dN/dS = 0.01
what’s the biological meaning between two group
how to explain their difference with this protein X
and please recommend some paper about this
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written
by
harrymao20 •
1 answer
You will need to calculate the confidence interval for each ratio. If human/mus is significantly smaller than fish/urchin, then you could argue that the gene divergence is smaller for human/mouse. However, you will need to be careful to take overall divergence into consideration as well.
For example, this paper mentions comparsions of divergence rates at different locations in the same species (where bootstrapping was used to define the confidence interval):
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.0020163
However, your comparison is tricker because your simulation will have to take the background subsitution rates into consideration
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