Interpreting noncoding phenotypically associated variants is an indispensable step to understand molecular mechanism of complex traits, GWAS3D systematically compute the probability of genetics variants affecting regulatory pathways and underlying disease/trait associations by integrating chromatin state, functional genomics, sequence motif, and conservation information when given GWAS data or variant list. GWAS3D also provided comprehensive annotations and visualizations to help users interpreting the results.

Main Functions

• Identify the most probable functional variants which affect transcriptional regulation;
• Prioritize the leading variants when given a full list of GWAS result;
• Evaluate the deleteriousness of genetic variants affecting the gene regulation when given a list of variants;
• Annotate genetic variant from regulatory perspective.

http://jjwanglab.org/gwas3d/