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Best Way To Visualize Next Generation Sequencing Tumor Evolution In A Graphic?

I have a good deal of NGS data with Normal, tumor, and Relapse samples. I would like a way of graphically depicting evolution regarding different mutations and genetic events. I have data on point mutants, CNV, and fusions but no good way to represent it as an evolving tumor. Does anyone know of a figure, program, or style of graphic that would be great in vizually showing important genetic changes in tumor evolution across many samples? Any help greatly appreciated.

ngs evolution sequencing
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updated by Malachi Griffith Malachi Griffith • written by Wayne Wayne

2 answers

How about something like the depiction used in Figure 2 of this paper: Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Ding et al. 2012

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written by Malachi Griffith Malachi Griffith

This is beautiful.

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written by Daniel Daniel

Hello,

Do you know with which Software they did this figure ?

Thank you

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written by xenia • xenia

Some previus examples only show key points suring tumor progression, such as http://www.pnas.org/content/105/11/4283/F5.large.jpg

In your case, maybe you can plot some karyograms showing coverages, duplications and marking all events as occured in time. Please share your plot ...

• 19 views • link
written by JC JC

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