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Formula Of Power/Sample Size Calculation In Gwas

Genetic Power Calculator

Just like the web-based tool in the above link does, we provide some parameters then we get power and sample size estimates under different genetic models. But I want to know the formula behind these calculations. I searched for literature but got no really helpful paper/tutorial. Could you point me to some references? Thank you very much.

gwas
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updated by Neilfws Neilfws • written by nnlnn • nnlnn

1 answer

"Genetic power" is really just an implementation of the more general concept of statistical power. I'd start with the Wikipedia entry, then a Google search for "statistical power" + gwas should return lots of relevant hits. For example:

Designing Genome-Wide Association Studies: Sample Size, Power, Imputation, and the Choice of Genotyping Chip

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written by Neilfws Neilfws

Thanks. I found this paper "Case-Control Studies of Genetic Markers: Power and Sample Size Approximations for Armitage’s Test for Trend", which seemingly is what I want.

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written by nnlnn • nnlnn

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