False positives in homology
I am wondering in case if there is a false positive in my homologs. How can we overcome the problem of false positives in homology?
• 876 views
•
link
written
by
Paul Paodumai •
0 answers
No answers yet.
Log in to answer this question.
More posts like this
-
Assigning weights to Classifiers based on AUC values
written by siu
-
Finding the Homologous sequences
written by siu
-
Problem in understanding False Discovery Rate (FDR)
written by deep771992chanda •
-
Approaches in metagenomics
written by Paul Paodumai •
-
VCF Normalisation is required ?
written by pinn
-
Homologs between tomato and Arabidopsis
written by I0110
-
Any comparisons of read length for variant calling?
written by Sukhi Singh
-
genotype calling,definition of false negative and false positive
written by tonja.r
-
Ancestral homolog assignment
written by nbeveryday •
-
Resolving Protein Identification Conflicts
written by Graslevy
This question needs far more detail in order to be answerable.
For starters: how is this list of homologues produced? In what sense are you considering something a false positive?
Homologs are defined as pairs of sequences related to each other by common evolutionary decent from a common ancestor. Because the definition requires knowledge about the deep past that is impossible to ever have, it is philosophically impossible to know whether two sequences are genuinely homologs.