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Bowtie2 and hisat2 indexes

Hello! Can someone expleined the difference between Bowtie2 and hisat2 indexes. I mean can I use bowtie2 index in hisat2 aligning?

thanks in advance

bowtie2 hisat2 rna-seq chip-seq

1 answer

No you can't (LINK).

Hisat2 uses some code from Bowtie2 but makes use of a different underlying index (first it was a hierarchical FM index, now its a hierarchical graph FM index) that is more cache friendly than what Bowtie2 uses (a relatively standard FM index).

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