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What is the minimum LDA score I can take for LefSe analysis?

Hi, I am doing differential abundance analysis and finding out biomarker from gut metagenomic sequences. For biomarker analysis, I am using the LefSe tool which has a default LDA score of 2.00. Can I lower this cut-off and still can consider significantly different taxa as a biomarker? If yes, which minimum value I can take?

Thanks

sequencing
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written by dpc dpc

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