Co expression scRNA-seq
Is it meaningful to calculate average expression of genes from cells in a cluster (consider them as pseudo-bulk - by doing this, I will have log10 (average expression) per cluster) and using these log-normalized cluster-averages, perform a co-expression analysis (pairwise Pearson or bicor correlations) to find coexpressed gene networks that exist across cell clusters? What are the limitations to this approach?
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Wocher33 •
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tigeradab
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