Modularity Of Transcription Factors
I attended a seminar about neurogenesis that presented results for PAX6 as an important TF that contains 3 domains with very distinct patterns of downstream expression. The speaker ended up saying that PAX6 can be considered as 3 TFs in one protein, acting independently in different situations.
Does anybody know of more examples like this?
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Check this paper http://www.nature.com/ng/journal/v31/n1/abs/ng881.html
Cross-posted here: http://biology.stackexchange.com/questions/2462/modularity-of-transcription-factors