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difference between bcftools mpileup and bcftools call

i would like to know the difference between bcftools mpileup and bcftools call , and why we index vcf file ?

Thank you

bcftools mpileup call variant

VCF files (and other files that contain records which are usually accessed at random) benefit from indexes the same way books do - it makes the lookup process faster as one knows exactly which memory location (like page number) to go to.

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