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Do tools doing clonal evolution analysis work on unmatched samples too

Hi

I have biopsies of pre chemotherapy patients and biopsies of post chemotherapy of different patients I mean pre and post treatment biopsies are not the same patients I want to look at the clonal evolution of tumour following chemotherapy hopefully to find resistant clones or anything meaningfully happen by treatment

Can I still use tools like scieclone software?

I have asked this from the developer but no answer yet

Please you may share your idea with me

Thanks

cnv wgs software scieclone
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updated by Biostar Biostar • written by zizigolu zizigolu

1 answer

If they are different patients, then they are different clones. Clonal analysis is used to track the same clones across different time points.

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written by igor igor

Yes they are different patients. So do you know a way to find the resistant clones from unmatched patients?

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written by zizigolu zizigolu

Then you can compare specific variants. For example, mutation X is present in one group, but not the other.

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written by igor igor

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