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Why some genes with negative fold change are assigned as activated upstream regulators by IPA?

Hi,

I used Ingenuity Pathway Analysis (IPA) to do upstream regulator analysis for my differentially expressed genes (relapse vs. non-relapse).

I realize some of the the genes that IPA predicted them as activated upstream regulators have negative expression ration in my relapse group.

How we can explain this?

Many thanks!

ipa upstream regulator activation z-score

Please contact IPA tech support to get an authoritative answer.

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