Can A Dna Binding Domain Serve As A Docking Site?

This might sound naive yet the question relates to bifunctionality of specific sites. Would it be possible to identify a site that is known binding site at the same time serves as a docking site?

docking sequence dna domain

• 2,741 views • link

updated 12.5 years ago by Biostar

• written 15.7 years ago by Eminencegrise

1 answer

yes it can, here is one example: The MDM2 Ubiquitination Signal in the DNA-Binding Domain of p53 Forms a Docking Site for Calcium Calmodulin Kinase Superfamily Members

• 2 views • link

written 15.7 years ago by Rm

Thank You that is of great help

• 0 views • link

written 15.7 years ago by Eminencegrise

More posts like this

Create genomic features/tracks from ChIP-seq data?
written 7.2 years ago by ejwright •

I'm currently using DANPOS2 to profile nucleosome occupancy genome-wide using data from an MNase-seq experiment. We're interested in changes in nucleosome occupancy related to a …
Comparing Protein-DNA binding species at specific time points
written 8.7 years ago by Hushus •

Hello world, I have the following [from different published sources]: 1) [Protein of Interest] TF binding data at different time points in development (ChIP) 2) …
Can blind docking be used to determine which ligands are most likely to bind a known binding site?
written 8.8 years ago by Alonzo •

I know that blind docking is most often used to determine an unknown binding site, but can it be used to determine whether a ligand …
how to specify residues as binding sites in docking
written 9.6 years ago by allenloong93 •

Hello, I'm a beginner with docking and wonder that could it possible to specify some residues as binding sites for small molecular virtual screening. I …
Steps to take before doing virtual screening
written 10.8 years ago by sakurashirleyke •

As what I known, before doing virtual screening (Structure-based), it is commonly to do this following: 1. Energy Minimization and 2. Binding Site Prediction for …
How To Perform Peptide-Protein Docking
written 12.8 years ago by Free Man

Hi, could anybody give me an example about how to perform peptide-protein docking: the software and steps? Here is my problem: (1) a peptide about …
Molecular Docking With Gold - How To Define A Ligand Binding Site?
written 15.5 years ago by Pals

I have been using the latest version of GOLD for docking ligand (Sugar substrate, GDP-Man) to the binding site of protein structure. After the docking …
Would Anyone Recommend A Novel Visualization Tool For Statistical Plots?
written 15.7 years ago by Eminencegrise

I am using MATLAB to produce anything and everything. The question is not specific, yet if there is novelty in the field I would not …
What Sequence Features Are Of Greatest Importance In Prediction Of Protein Protein Docking?
written 15.8 years ago by Eminencegrise

My questions pertains to features that can solely be derived from sequence. Would You think the that docking domains are specific to terminal regions? In …
Is There A Docking Domain Database For Confirmed Plant Protein-Protein Interaction Sites?
written 15.9 years ago by Eminencegrise

I am trying to construct a network. I am trying to predict new docking domains yet I would not want to miss out on the …