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please evaluate my experiment design

I have Whole Genome sequencing DNA data of children sarcoma tumor ( many types of sarcoma i have)

In research paper, i read the children are more affected by heredity factors than environment factors.

Thus, i'm gonna prepare Germline, Somatic calling pipeline, and also copy number.

additionally, based on the children cancer have long term cure need, I have necessity of finding recurrent mutation.

Thus i found the paper

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

and i'm gonna use tools or pipeline in that paper.

Because i'm the new on bioinformatics, i cannot sure what my plan is logically significant. Thank you.

snp snp next-gen sequencing genome
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written by 9521ljh • 9521ljh

Hi 9521ljh

Besides a vague question, the post is so poorly structured and grammatically incorrect. Nobody is going to spare time reading this. I would suggest you re-write this post in bullet points if you think English is a barrier in this case.

  1. Re-think of your title
  2. Write using the following bullet points
  • Your objective - what is the end goal? what question you think you need to answer?
  • Your efforts - show us what have you tried so far? what did you understood and what is remaining?
  • Ask specifically - pin point on the information that you are seeking. The more you narrow down the question, the more people can help you

Highly recommended to read these posts:

How To Ask Good Questions On Technical And Scientific Forums

Brief Reminder On How To Ask A Good Question

All the best

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written by lakhujanivijay lakhujanivijay

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