422/5000 Hello. Help me interpret the output of Trininty/edgeR from differential expression analysis. It generates two files, one with UP-expresssion for SampleA and one with UP-expression for SampleB.

I know that logFC positive means UP-expression and logFC negation down-expression. Why in the output of UP-expressed from SampleB is the logFC negative? Can someone help me to interpret this data?

the summary of the sample outputs:

sampleA UP-expression

enter code here sampleA sampleB logFC   logCPM  PValue  FDR diseased    healthy
enter code here TRINITY_DN20_c0_g1_i1   diseased    healthy 11.547219358876 6.46292409746543    9.85640289124254e-24    2.15436326195334e-19    219.127 0.069
enter code here TRINITY_DN2989_c0_g1_i11    diseased    healthy 14.4550438923786    5.66470792550252    4.15351643702967e-22    4.5392742761188e-18 162.136 0.000
enter code here TRINITY_DN6792_c0_g2_i10    diseased    healthy 14.2844065813709    5.49525087238527    1.34541228845186e-21    8.87815749571852e-18    77.118  0.000

sampleB UP-expression

enter code here sampleA sampleB logFC   logCPM  PValue  FDR diseased    healthy
enter code here TRINITY_DN325_c0_g1_i7  diseased    healthy -13.0824601986213   7.08358351895648    1.96212428498806e-27    1.71548526236506e-22    0.000   46.006
enter code here TRINITY_DN325_c0_g1_i1  diseased    healthy -12.1211236235678   6.12036009218274    1.51458619514056e-24    6.62101355205698e-20    0.000   23.937
enter code here TRINITY_DN7303_c0_g1_i6 diseased    healthy -14.6691392658181   5.86419527682427    8.82661700411335e-24    2.15436326195334e-19    0.000   45.195

Help me