Why fully functional protein monomer still dimerise ?
Hello there
Some proteins are fully functional as a dimer but most of their crystal structures show a dimer or even a tetramer. Why they still dimerise if they can function as monomer?
Thank
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Hello db4!
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https://www.researchgate.net/post/How_can_I_know_if_my_protein_a_monomer_or_dimer
This is a wet-biology question, but it's interesting.
To determine how many subunits your protein has you need analytical ultracentrifugation.
The link above describes this phenomenon - protein in solution and protein in crystal
may behave in a different way.