Why do BRAF mutations appear more in skin cutaneous melanoma?
When looking at the tissue expression of the BRAF protein it seems that BRAF is regularly expressed in almost all of the tissues. Yes, there is elevated expression in tissues like the Testis and the Parathyroid gland, but the expression in the Skin is about average. So how does it make sense that for example in tumor samples of skin cutaneous melanoma (TCGA-SKCM) the BRAF mutations are so dominant (about 50% of the cases contain a BRAF mutation)?
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Hello rafi.zon!
We believe that this post does not fit the main topic of this site.
Not a bioinformatics-related question. Please search google and PubMed first, and if this does not help, try StackExchangeBiology of Reddit.
For this reason we have closed your question. This allows us to keep the site focused on the topics that the community can help with.
If you disagree please tell us why in a reply below, we'll be happy to talk about it.
Cheers!
FYI, to other Biostars users, this question was re-opened. So, if cancer-specific questions about mutation calling are possibly relevant, you can talk about either the biology or mutation calling in this thread.
I also didn't previously know about Biology Stack Exchange, so that was a nice pointer for people to consider in the future (for things that are less relevant for Biostars).