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How to annotate structural variants in VCF with esv/nsv identifiers

Hi!

I'm struggling with finding a way to annotate a manta structural variants VCF output with SV regions identifiers from DGV/dbVAR (esv/nsv). Direct annotation based on the exact reported chromosomal positions certainly would not work as most of the structural variants have imprecise start-end locations. I did not manage to find the desired functionality in VEP, snpeff, annovar and loads of other tools reported elsewhere. I would appreciate any information on this issue.

Thanks! Kirill

sv esv nsv annotation vcf

Thank you. Actually, I've come across this tool while googling but did not manage to comprehend its ability to do so. Now I do. I'll try it and post the result.

vcfanno works very well, I can recommend it.

if you still need help I can help you

1 answer

Can you please help on this ?

My SV caller has been Manta, my script does annotation on Manta. What is your SV caller?

yes Its manta. Primarily I am using MANTA for that.

You may need to install Ruby

I hope this helps

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