Hello, I'm working on a project that involves paired (case-control) pool sequencing to investigate the genetic factors in trees. I've observed inflation in QQ plots …

I love .gfa, but sometimes I have trouble to understand them. I have used Flye with pacBio reads with defaults options to make a first …

Hi all, I have a problem running the PHG `ImputePipelinePlugin` plugin with inputType=**vcf** and imputeTarget=**diploidPathToVCF**. I'm using PHG version 0.026. To be exact, I manage …

I have been going around a problem for a 2 days while uploading data to the Michigan imputation server. Any help is much appreciated! I …

Hey colleagues, Summary some good habit in our research. I have been hit by the project badly since some bad habit, such as: 1. Record …

###Hi all! Whilst fiddling around with the BAM format, I was a little surprised to see that since it supports the IUPAC codes when encoding …

I'm still rather new with bioinformatics and as such I've been trying to establish my own "process" of sorts in regards to finding, understanding and …

[Heng Li][1] is a research scientist at the [Broad Institute][2], working with [David Reich][3] and [David Altshuler][4]. Dr. Li received his PhD from the Institute …

I am working on my thesis and the goal for that is to develop a molecular biomarker for the detection of testicular cancer, in order …

<p>Hi,</p> <p>I'm performing for the first time SNP calling using GATK. I'm following the pipeline proposed in <a href='http://biostar.stackexchange.com/questions/1269/what-is-the-best-pipeline-for-human-whole-exome-sequencing'>http://biostar.stackexchange.com/questions/1269/what-is-the-best-pipeline-for-human-whole-exome-sequencing</a> , although I haven't run the …