Entering edit mode
5.4 years ago
ccscience76
•
0
Hello
Im trying to figure out to use different tools to study de novo variants from whole exome sequence.
If I merge the parental bam files(marking duplicates later and so on) and I use somatic variant caller from Varscan against the child, the results shouldn't be a bit similar if I use directly de novo(trio) caller tool from Var Scan?
Maybe this sounds a bit weird...but I would appreciate if someone can explain to me.
Thanks