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question about survival analysis

Hi,

I have a set of genes (~1000 genes) which share a common feature. I want to perform survival analysis to identify prognostic genes from this gene set. I choose genes with Cox-pvalue<=0.05 and regard these genes as prognostic genes. However, someone told me that I should use the adjusted pvalue to determine prognostic genes.

Is it reasonable to use raw Cox-pvalue to determine prognostic genes? Or I must do the multiple correction?

survival analysis;multiple test correction
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written by tujuchuanli tujuchuanli

Thanks, Kevin. you help me a lot!!

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written by tujuchuanli tujuchuanli

1 answer

Usually the log rank p-value is chosen, and I have seen situations where this is both adjusted and not adjusted for FDR. I go over a similar thing here: Survival analysis with gene expression

For a more 'intimate' response on adjusting p-values for Cox models, I would go to https://stats.stackexchange.com/

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written by Kevin Blighe Kevin Blighe

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