HI all,

We have performed several RNAseq experiments with multiple replicates and different conditions. Our results show us promising deregulated genes that we want to further investigate. On those genes we wanted to find out whether there is presence of variants (not rare variants) that may impact the pathways which those genes are involved.

At this point I defined some criteria for the variants I'm interested:

• Variants should follow the Hardy-Weinberg Equilibrium
• Should be a common variant
• Should affect mainly European populations

In order to find variants following above criteria for a set of genes, what would you recommend? There's any resource to go through? R package? I'm asking this because I'm quite new in this field, so I wanted the opinion of experts.

Thanks!