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protein profile from alignment

Hey is there a tool like biopython or cmd program that do profile from protein alignment? And a tool that can comparison profile from db of profiles?

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protein alignment python profile

that do profile from protein alignment


that can comparioson profile from db of profiles

You'll have to explain what you are looking for a bit more in detail.

I mean - from protein alignment make a profile (somekind ie. freq profiles) I found EMBOSS prophecy. Did someone know something else? And the problem I've got is to find database of well prepered profiles. And program which do comparison of those profiles. could you recommend something?

3 answers

Pfam is a good database of profiles, and HMMER is the program used to create and compare these profiles.

HHmake will make hmm profile & hhsearch will compare query profile to db of profiles.

https://github.com/soedinglab/hh-suite

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