Transcription factor enrichment analysis
Hi everyone
I am trying to run Fisher exact test for transcription factor enrichment analysis: I have 1017 genes from group A, 44 genes from group B, transcription factor X is present in 440 A genes and 27 B genes. Python fisher exact test:
fisher_exact([[27, 440], [17, 577]])
gives 0.02 pvalue, I am not sure how to interpret it. Does it mean the enrichment of X factor in B genes? And is Fisher appropriate, when I have gene sets that differ so much in sizes? And if not, what test should I use?
Thank you
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chipolino •
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