Comparing lists of samples: gene expression analysis in cBioportal

Question

[oliver.hickman]

I am trying to use the cbioportal interface to compare gene expression for two selected groups of samples within a dataset.

Example:

Using patient metadata I have divided the TCGA for breast cancer patients into two groups. 1 and 2.

I now want to pull out gene expression data for these two groups. Possibly draw upa list of most differentially expressed genes between these two groups?

Is this possible, and if so how? Please do not assume a lot of knowledge on my part, keep the jargon to minimum!

Thanks in advance.

O.

[Kevin Blighe]

Which IDs are you using for your groups? - TCGA barcodes?; UUIDs? You could just obtain the mRNA Expression z-Scores for all of your genes of interest and then divide that dataset up based on your groupings.