Pathway Analysis and hypergeometric distribution
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6.0 years ago
Mozart ▴ 330

Hello there, I am trying to understand the idea behind pathway analysis and how they try to reduce gene redundancy across multiple pathways. I have just some general idea behind gene-length bias (the higher is the gene length the more likely it is differentially expressed) but I don't really get why the hypergeometric distribution is important in this sense and how it can be useful to reduce this bias.

thanks in advance.

gene RNA-Seq • 1.2k views
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