Where can I find the histone modification marks for dementia-related diseases
Hi,
I am looking for histone modification marks (preferably H3K4me3, or H3K27ac) profiled in different dementia-related diseases e.g. Parkinson's and Alzheimer's disease. I have looked into many resources (GEO, arrayExpress, repositive) but no luck so far. Can anybody point me out towards a specific study or such dataset available in disease-control condition, ideally from postmortem brain tissues.
Thank you.
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LONI is one of the largest repositories (if not the largest) of data for Alzheimer's and Parkinson's, however, unfortunately, they did not do ChIP profiling.
Your starting point may be some of the reviews that have been published on this specific area:
The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review.
Role of epigenetics in Alzheimer's and Parkinson's disease.
Epigenetics in Parkinson's and Alzheimer's diseases.